When the COVID-19 Vaccine is distributed, maintaining the cold chain is the critical first step in vaccine inventory management. Vaccine deliveries should only be scheduled at times when staff will be present because vaccines must never be left unattended. To support efficient distribution of the COVID-19 Vaccine, full day receiving hours should be available. When that is not possible, locations receiving vaccine and ancillary supply shipments must be available during a four-hour window on a weekday other than Monday. All COVID-19 vaccine and ancillary kit deliveries will require a signature. For detailed guidance, please refer to the CDC’s Vaccine Storage and Handling Toolkit. For storage and handling for current COVID-19 vaccines, also refer to Pfizer-Biontech and Moderna guidance.